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gregorian
>2012
>October-December
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23407750
Host-Microbiota Interaction is MyD88-Independent in the Intestinal Tract under Physiologic Condition
The role of microbiota in health and disease is the subject of rigorous investigation. Several studies have demonstrated that microbiota and the pattern-recognition receptors contribute to intestinal tumourigenesis; the exact mechanism of which is still obscure. MyD88 is the downstream effector of all Toll-like receptors (TLRs) except TLR3. However, the alternative MyD88-independent pathway is functional downstream of not only TLR3, but also TLR1/2, 2/6, 4, and 5. TLR4 stimulation with intraperitoneal lipopolysaccharide exerts distinct functional effect on the intestinal motility via MyD88-dependent and-independent pathways.
Host-microbiota interaction, Intestinal tract, Toll-like receptors
210
211
https://www.ajmb.org/En/Article.aspx?id=102
https://www.ajmb.org/PDF/En/FullText/102.pdf
ShirinMoossaviDigestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran411
NimaRezaeiDepartment of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield, , Sheffield, UK186