en 38618504 <p style="text-align:justify"><span style="font-size:11pt"><strong><span style="font-size:10.0pt">Background:</span></strong><span style="font-size:10.0pt"> Exposure to pesticides is of concern to public health officials worldwide. Deltamethrin is a synthetic <span style="color:black">pyrethroid </span>pesticide which is widely used in agriculture and veterinary medicine. Deltamethrin poisoning is always one of the concerns in medical centers</span><span style="font-size:10.0pt"> due to the </span><span style="font-size:10.0pt">deltamethrin induced </span><span style="font-size:10.0pt">hepatotoxicity.</span><span style="font-size:10.0pt"> This study evaluated the hepatoprotective effects of N-acetylcysteine (NAC) against deltamethrin induced hepatotoxicity in mice</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><strong><span style="font-size:10.0pt">Methods:</span></strong><span style="font-size:10.0pt"> A total of 40 BALB/c male mice were randomly divided into four groups; the first group was used as a control (0.5 <em>ml</em> normal saline); Groups 2-4 were treated with NAC [160 <em>mg/kg</em> Body Weight (BW)], deltamethrin (50 <em>mg/kg</em> BW), and NAC plus deltamethrin. At 1 and 24 <em>hr</em> after treatment, the animals were sacrificed and blood and liver samples were obtained for analysis and the liver/body ration, hepatic enzymes as </span><span style="font-size:10.0pt">Aspartate aminotransferase (AST), Alanine Transaminase (ALT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH), Glutathione</span><span style="font-size:10.0pt"> (GSH) content and <span style="background-color:white"><span style="color:black">Reactive Oxygen Species</span></span> (ROS) level were measured. For comparison between more than two experimental groups, one-way ANOVA following Tukey test was used by SPSS software.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><strong><span style="font-size:10.0pt">Results:</span></strong><span style="font-size:10.0pt"> The deltamethrin significantly increased AST, ALT, ALP, and the level of ROS level at the end of 1 and 24 <em>hr</em> after treatment; while the LDH level and GSH content were decreased. Mice in the deltamethrin treated group had a higher liver/body weight ratio than in other treated groups after 24 <em>hr</em>. On the other hand, NAC in combination with deltamethrin significantly reduced the activities of AST, ALT, ALP, and increased GSH levels.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><strong><span style="font-size:10.0pt">Conclusion:</span></strong><span style="font-size:10.0pt"> This study demonstrated that NAC has a hepatoprotective role against deltamethrin-induced toxicity.</span></span></p> Deltamethrin, Hepatoprotection, Liver, N-acetylcysteine, Pesticides 88 94 https://www.ajmb.org/En/Article.aspx?id=60571 https://www.ajmb.org/PDF/En/FullText/60571.pdf AliAmeriStudent Research Committee, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran92154AlirezaRahmatiStudent Research Committee, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran92155ShadiSoroushfar Student Research Committee, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran92156MehdiLalehzariTrauma Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran92157TaherehDehghaniInfectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran92158HamedHaghi-AminjanPharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran92159JebreilShamseddinInfectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran92160MahmoudOmidiDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran92161