en 23407576 The aim of the study was to study the anti-ulcer activity of the methanolic extract of the leaves of Capparis zeylanica Linn on experimental animal models. The methanol extract of Capparis zeylanica Linn. leaves was investigated for anti-ulcer activity against aspirin plus pylorus ligation induced gastric ulcer in rats. HCl-Ethanol induced ulcer in mice and Indomethacin induced ulcer in rats at 200 mg/kg body weight p.o. A significant (p<0.01, p<0.001) anti-ulcer activity was observed in all the models. Pylorus ligation showed significant (p<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. It also showed 88.5% ulcer inhibition in HCl-ethanol induced ulcer and 83.78% inhibition in Indomethacin induced ulcer. Aspirin, Indomethacin , Rats, Plant extracts, Mice, Gastric ulcer 1 5 https://www.ajmb.org/En/Article.aspx?id=56 https://www.ajmb.org/PDF/En/FullText/56.pdf KaranayilR.SiniDepartment of Pharmaceutical Chemistry, Grace College of Pharmacy, Palakkad, India198BarijN.SinhaDepartment of Pharmaceutical Sciences, Jharkhand, India199AiyoluRajasekaranKMCH College of Pharmacy, Coimbatore, India200