en 33680373 <p><span style="font-size:11pt">Background: The present study aimed to investigate the antifungal activity of Nanoparticles (NPs) against amphotericin B-resistant <em>Candida glabrata</em> (<em>C. glabrata</em>) strains. </span></p> <p><span style="font-size:11pt">Methods: Twelve resistant (<em>C. glabrata</em>) strains were isolated from archived clinical isolates. Antifungal activity was conducted according to Clinical and Laboratory Standards Institute&rsquo;s (CLSI) guidelines, document M27-A3/S4. The Scanning Electron Microscope (SEM) was used to observe the morphological changes of strains exposed to each nanoparticle. </span></p> <p><span style="font-size:11pt">Results: Minimum Inhibitory Concentration (MIC) of nanoparticles of all strains was in the concentration range of 0.125 to 0.5 <em>&micro;g/Ml</em>. The synthesized Ag-NPs showed superior antifungal activity against (<em>C. glabrata</em>) compared to Se-NPs and Au-NPs. The scanning electron microscope images revealed the difference in the fungal morphology between the untreated and treated fungi with nanoparticles. </span></p> <p><span style="font-size:11pt">Conclusion: The Ag-NPs, followed by Se-NPs synthesized, revealed significant antifungal activity against resistance regardless of their antifungal-resistant mechanisms.</span></p> Antifungal agents, Candida glabrata, Nanoparticles, Silver 47 50 https://www.ajmb.org/En/Article.aspx?id=40447 https://www.ajmb.org/PDF/En/FullText/40447.pdf EnsiehLotfaliDepartment of Medical Parasitology and Mycology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran61687HosseinToreyhiStudent Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran61688KamyabMakhdoomi SharabianiStudent Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran61689AzamFattahi61690AmiraliSoheiliStudent Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran61691RezaGhasemiStudent Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran61692MahyarKeymaramDepartment of Medical Parasitology and Mycology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran61693YasamanRezaeeStudent Research Committee, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran61694SaynaIranpanahStudent Research Committee, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran61695