en 30090209 <p>Background: The purpose of this study was to investigate the sterol profiling and predict the pharmacological potential of marine gastropod <em>Telescopium telescopium (T. telescopium)</em>, collected from mangrove ecosystem in the South west coast of India.<br /> Methods: Sterol fractions were separated from the crude lipids using 15% ethyl acetate. Ethyl acetate fractions were dried under ultrahigh purity N₂ and analyzed using GC-MS. The biological activity was predicted using the software CLC-Pred; <em>In silico</em> predictions of cytotoxicity for tumor and non-tumor cell lines and PASS.&nbsp;<br /> Results: This study proved the existence of four sterols, of which cholesterol was abundant. It was found that most of the steroids profiled from <em>T. telescopium</em> displayed activity against reproductive system as well as skin related diseases.&nbsp;<br /> Conclusion: The predicted anti infertility and skin related activity of the steroids identified from the marine gastropod <em>T. telescopium</em> is useful to attract industrial interest towards this species which will be helpful in rising new combinations with added therapeutic and nutritional worth.</p> CLC-Pred, PAAS, Telescopium telescopium 158 162 https://www.ajmb.org/En/Article.aspx?id=322 https://www.ajmb.org/PDF/En/FullText/322.pdf ARagiDepartment of Chemical Oceanography, Faculty of Marine Sciences, Cochin University of Science and Technology, Cochin, India1293PLeenaInter University Center for Development of Marine Biotechnology, Cochin University of Science and Technology, Cochin, India1294KPrashob PeterDepartment of Chemical Oceanography, Faculty of Marine Sciences, Cochin University of Science and Technology, Cochin, India1295SNairInter University Center for Development of Marine Biotechnology, Cochin University of Science and Technology, Cochin, India1296