en 28090279 <p>Background: ATP-binding cassette transporter A1 (<em>ABCA1</em>) is a membrane integral protein which plays a vital role in High Density Lipoprotein (HDL) metabolism and exerts a protective effect against Hypoalphalipoproteinemia (HA) by mediation of rate-limiting step in HDL biogenesis. In addition, this protein possesses anti-inflammatory effects by inhibiting the production of some inflammatory cytokines in macrophages. This study investigated the association of <em>ABCA1</em>-565 C/T gene polymorphism with HA and serum lipids, IL-6 and CRP levels.<br /> Methods: A population which consisted of 101 HA and 95 normal subjects were genotyped for <em>ABCA1</em>-565C/T polymorphism by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The serum concentrations of lipids, IL-6 and high sensitive-CRP (hs-CRP) were measured by the relevant methods.<br /> Results: The frequency of T allele was significantly higher in the HA group than the controls (31.7 <em>vs</em>. 19.5%, p=0.002). Thus, carriers of the T allele (CT and TT genotypes) had a higher risk for HA (p=0.016, OR=2.04, 95% CI=1.14-3.63). T allele carriers demonstrated decreased HDL-C and increased triglyceride, IL-6 and CRP levels than those with the CC genotype. &nbsp;<br /> Conclusion: This study suggests that the-565 C/T polymorphism of <em>ABCA1</em> gene is associated with an increased risk of HA, decreased HDL-C and increased TG, IL-6 and CRP.</p> -565 C/T polymorphism, ABCA1, CRP, Hypoalphalipoproteinemia, IL-6, Lipids 38 43 https://www.ajmb.org/En/Article.aspx?id=265 https://www.ajmb.org/PDF/En/FullText/265.pdf Mohammad MahdiBabashamsiDepartment of Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran1091SohrabHalalkhorDepartment of Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran1087HamidMoradi FirouzjahDepartment of Molecular and Cell biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran1090HadiParsianDepartment of Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran1089Seyed FarzadJalaliDepartment of Cardiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran1088MohammadBabashamsiMonoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran34