en 27563424 <p>Background: Sporadic Alzheimer&rsquo;s Disease (SAD) is caused by genetic risk factors, aging and oxidative stresses. The herbal extract of <em>Rosa canina (R. canina)</em>, <em>Tanacetum vulgare (T. vulgare)</em> and <em>Urtica dioica (U. dioica)</em> has a beneficial role in aging, as an anti-inflammatory and anti-oxidative agent. In this study, the neuroprotective effects of this herbal extract in the rat model of SAD was investigated.<br /> Methods: The rats were divided into control, sham, model, herbal extract -treated and ethanol-treated groups. Drug interventions were started on the 21^st day after modeling and each treatment group was given the drugs by intraperitoneal (I.P.) route for 21 days. The expression levels of the five important genes for pathogenesis of SAD including <em>Syp, Psen1, Mapk3, Map2</em> and <em>Tnf-&alpha;</em> were measured by qPCR between the hippocampi of SAD model which were treated by this herbal extract and control groups. The Morris Water Maze was adapted to test spatial learning and memory ability of the rats.<br /> Results: Treatment of the rat model of SAD with herbal extract induced a significant change in expression of <em>Syp</em> (p=0.001) and <em>Psen1</em> (p=0.029). In Morris Water Maze, significant changes in spatial learning seen in the rat model group were improved in herbal-treated group.<br /> Conclusion: This herbal extract could have anti-dementia properties and improve spatial learning and memory in SAD rat model.</p> Alzheimer disease, Gene expression, Herbal extract 120 125 https://www.ajmb.org/En/Article.aspx?id=244 https://www.ajmb.org/PDF/En/FullText/244.pdf ParvanehDaneshmandGenetic Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran1006KioomarsSaliminejadReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran393MarziehDehghan ShasaltanehLaboratory of Neuro-organic Chemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran1007KooroshKamaliReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran89Gholam HosseinRiaziLaboratory of Neuro-organic Chemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran1008RezaNazariLaboratory of Neuro-organic Chemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran1009PedramAzimzadehBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran1010Hamid RezaKhorram KhorshidGenetic Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran42