en 25414781 <p>Vascular endothelial growth factor (VEGF-A) is one of the most important regulatory factors in pathological and physiological angiogenesis. Alternative splicing is a complicated molecular process in VEGF-A gene expression which adds complexity to VEGF-A biology. Among all VEGF-A exons, alternative splicing of exon 8 is the key determinant of isoform switching from pro-angiogenic VEGF-xxx to anti-angiogenic VEGF-xxxb. This is known as a key molecular switching in many pathological situations. In fact, the balance between VEGF-xxx and VEGF-xxxb isoforms is a critical controlling switch in both conditions of health and disease. Here, the properties of VEGF-xxx and VEGF-xxxb isoforms were discussed and their regulatory mechanism and their roles in certain pathological processes were evaluated. In summary, it was suggested that C-terminal VEGF-A alternative splicing can provide a new treatment opportunity in angiogenic diseases.</p> Alternative splicing, Angoigenesis, Disease, Health, Vascular endothelial growth factor A 192 199 https://www.ajmb.org/En/Article.aspx?id=186 https://www.ajmb.org/PDF/En/FullText/186.pdf FaribaDehghanianDepartment of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran789ZohrehHojatiDepartment of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran405MaryamKayDepartment of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran791