en 23407575 Although, coumarins are a group of compounds which are naturally found in some plants, they can be synthetically produced as well. Because of their diverse derivatives, origin and properties most of them can be used for medicinal purposes. For example, they can be used against fungal diseases or in studying structure and biological properties of antifungal agents to discover new compounds with the similar activity. A Structure Property/Activity Relationship (SAR) can be utilized in prediction of biological activity of desired molecules. Antifungal activity, Coumarin, Modeling, Neural network 95 103 https://www.ajmb.org/En/Article.aspx?id=12 https://www.ajmb.org/PDF/En/FullText/12.pdf SaeedSoltaniMedical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran , Tehran, Iran52ShimaDianatMedical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran , Tehran, Iran53SoroushSardariMedical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran , Tehran, Iran54