en 30555661 <p>Background: Mutations in the coding region of the Chemokine Receptor 5 (<em>CCR5</em>) genes reduce or eliminate <em>CCR5</em> expression in immune cells and progression of HCV infection. This study aimed to investigate the role of this mutation in HCV infection in Iranian patients in comparison with healthy individuals.<br /> Methods: 100 HCV infected patients and 100 healthy individuals were randomly selected. The <em>CCR5&Delta;32</em> genotypes were determined using specific primers and PCR method.<br /> Results: The agarose gel electrophoresis showed a189-bp fragment from wild type for both alleles of <em>CCR5 </em>gene. The <em>CCR5-&Delta;32</em> allele was not found in any HCV infected and healthy subjects.<br /> Conclusion: The mutation in <em>CCR5</em> gene was not detected in any of the two groups; therefore, the role of<em> CCR5</em> gene expression in immune cells and progression of HCV infection needs to be studied in larger samples in our country.</p> CCR5 protein, Hepatitic C, Human, Infection, Mutation 261 264 https://www.ajmb.org/En/Article.aspx?id=10334 https://www.ajmb.org/PDF/En/FullText/10334.pdf FarahnazBineshianDepartment of Parasitology & Mycology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran11372AsiehHosseini Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran11373ZohrehSharifiBlood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran640AfsanehAghaieBlood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran11475