<p><span style="font-size:11pt"><span style="font-size:10.0pt">Menstrual-derived Stem Cells (MenSC) are a potential novel source of mesenchymal stem cells. There is an increased interest in investigating the therapeutic potential of MenSC due to the various advantages they exhibit</span><span style="font-size:10.0pt">, when </span><span style="font-size:10.0pt">compared to other types of stem cells. MenSC are obtained </span><span style="font-size:10.0pt">non-invasively </span><span style="font-size:10.0pt">from menstrual blood. Thus, collection of MenSC is simple, reproducible and can be </span><span style="font-size:10.0pt">carried out</span><span style="font-size:10.0pt"> periodically</span><span style="font-size:10.0pt">, </span><span style="font-size:10.0pt">with </span><span style="font-size:10.0pt">minimal </span><span style="font-size:10.0pt">complications. MenSC are present in abundance, are highly proliferative, exhibit a low immunogenicity</span> <span style="font-size:10.0pt">and lack ethical issues. MenSC have shown the ability to differentiate into several lineages. </span><span style="font-size:10.0pt">The</span><span style="font-size:10.0pt"> therapeutic potential of MenSC in non-gynaecological applications ha</span><span style="font-size:10.0pt">s</span><span style="font-size:10.0pt"> been investigated in wound healing, neurological, musculo-skeletal,&nbsp; cardiovascular, respiratory</span><span style="font-size:10.0pt">, and </span><span style="font-size:10.0pt">liver disorders, </span><span style="font-size:10.0pt">as well as in </span><span style="font-size:10.0pt">diabetes and cancer. Human clinical trials are limited</span><span style="font-size:10.0pt">. T</span><span style="font-size:10.0pt">o date, therapeutic efficacy and safety have been reported in patients with Avian influenza A subtype H7N9, </span><span style="font-size:10.0pt">COVID-19</span><span style="font-size:10.0pt">, congestive heart failure, multiple sclerosis and Duchene muscular dystrophy. However, further clinical trials in humans should be conducted, to study the long-term therapeutic effects of these stem cells in various diseases and to further explore their mechanism of action. This systematic review focuses on the application of MenSC in non-gynaecological diseases.</span></span></p>