Avicenna J Med Biotech

arij002

Avicenna Journal of Medical Biotechnology

2008-2835 2008-4625

Avicenna Research Institute

ajmb216

An Association Study on IL16 Gene Polymorphisms with the Risk of Sporadic Alzheimer’s Disease

Khoshbakht

Tayyebeh

Molecular Diagnostic Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Soosanabadi

Mohsen

Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Neishaboury

Maryam

Mirza Koochak Khan Hospital, Iran University of Medical Sciences, Tehran, Iran

Kamali

Koorosh

Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR , Tehran, Iran

Karimlou

Masoud

Mirza Koochak Khan Hospital, Iran University of Medical Sciences, Tehran, Iran

Bazazzadegan

Niloofar

Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Khorram Khorshid

Hamid Reza

Molecular Immunology and Vaccine Research Laboratory, Pasteur Institute of Iran , Tehran, Iran

7 3 128 132 5 12 2014 25 5 2015

Background: Interleukin-16 (IL-16) is an important regulator of T cell activation and was reported to act as a chemoattractant agent. There are evidences that IL16 can control the neuroinflammatory processes in Alzheimer’s Disease (AD). This study was performed to investigate the role or association of IL16 polymorphisms, rs11556218 and rs4778889 with the risk of late-onset Alzheimer’s disease (LOAD) in Iranian population. Methods: Totally, 148 AD patients and 137 nondemented and age-matched subjects were recruited in this study. Genotyping of rs11556218 T/G and rs4778889 T/C polymorphisms was performed by PCR-RFLP method using the NdeI and AhdI restriction enzymes, respectively. Results: Statistical analysis of rs11556218 genotypes showed a protective effect against AD in the heterozygote genotype (p=0.001, OR=0.16) as well as rs4778889 (p=0.001, OR=0.23). Frequency of rs11556218 allele T was higher in controls than patients (p=0.001, OR=0.32). However, there was no significant difference in the frequencies of rs4778889 alleles between the AD patients and controls.   Conclusion: Our results indicate that the rs11556218 and rs4778889 polymorphisms have a protective role in the development of sporadic AD in Iranian population.