Avicenna J Med Biotech arij002 Avicenna Journal of Medical Biotechnology 2008-2835 2008-4625 Avicenna Research Institute ajmb10392 Interleukin 10 and Transforming Growth Factor Beta Polymorphisms as Risk Factors for Kawasaki Disease: A Case-Control Study and Meta-Analysis RahmaniFarzanehZiaeeVahidAssariRahelehSadrMaryamDepartment of Biology, Research Center for Applied Biology, Mashhad Branch, Islamic Azad University, Mashhad, IranRezaeiArezouSadrZeinabRaeeskaramiSeyed RezaMoradinejadMohammad HassanAghighiYahyaRezaeiNimaBiotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran , Tehran, Iran 11 4 325 333 25 8 2018 15 10 2018

<p>Background: Alteration in serum expression of Transforming Growth Factor-beta (TGF-&beta;) and IL-10 have been suggested to play a role in the pathogenesis of Kawa-saki Disease (KD). Inconsistent reports exist on the association of IL-10 polymorphisms with KD susceptibility and Coronary Artery Aneurysms (CAA).&nbsp;<br /> Methods: A number of 110 paediatric patients with KD and 140 healthy individuals were recruited to investigate the frequency of Single Nucleotide Polymorphisms (SNPs) of TGF-&beta; C/T at codon 10 (rs1982073), C/G at codon 25 (rs1800471) and IL-10 A/G at -1082 (rs1800896), C/T at -819 (rs1800871) and A/C at -592 (rs1800872) and their respective genotype and haplotypes. A comprehensive search was performed in MEDLINE and SCOPUS using the keywords of interleukin 10, transforming growth factor beta, and Kawasaki disease. Moreover, previous studies investigating the TGF-&beta; and IL-10 polymorphisms in KD were evaluated. Review Manager Version 5.1 Software was used to perform meta-analysis.<br /> Results: There was no significant association between allelic or genotypic variants in the mentioned polymorphisms in TGF-&beta; or IL-10 with KD or CAA. The only significant haplotypic variant was TC variant at codon 10, and 25 of TGF-&beta; polymorphisms were associated with higher risk of KD. Meta-analysis of a total number of 770 patients vs. 1471 healthy controls showed no difference in the frequency of any of the IL-10 genetic variants in KD patients, regardless of the presence of CAA.<br /> Conclusion: Polymorphisms of TGF-&beta; or IL-10 are not associated with additional risk for KD in Iranian population. IL-10 polymorphisms at -1082, -819 and -592 positions are not associated with KD, nor do they predict coronary artery aneurysm formation.</p>