en
2008-2835
2008-4625
276
5669
11181
gregorian
>2020
>October-December
12
4
online
1
fulltext
en
33014317
Effective Anti-SARS-CoV-2 RNA Dependent RNA Polymerase Drugs Based on Docking Methods : The Case of Milbemycin, Ivermectin, and Baloxavir Marboxil
<p>Background: Severe Acute Respiratory Syndrome-coronavirus 2 (SARS-CoV-2) is a new virus with a global pandemic. Yet, no vaccine or efficient treatments are found against the disease. The viral RNA dependent RNA Polymerase (RdRP) is a suitable target for developing antiviral agents. SARS-CoV-2 RdRP was employed to test its binding activity with some drugs.</p>
<p>Methods: Using some docking methods, RdRP was targeted by Milbemycins (MMs), Ivermectin (IMT), Baloxavir Marboxil (BM), and Tadalafil (TF), a phosphodiesterase type 5 inhibitor.</p>
<p>Results: MM-A3 5-oxime (MMA35O), MM-A3 (MMA3), MM-A4 5-oxime (MMA45O), IMT, BM, and TF showed the highest binding affinity to RdRp.</p>
<p>Conclusion: The drugs used in the present computational investigation are effective against the SARS-CoV-2 RdRP with high affinity values especially, milbemycins, ivermectin, and Baloxavir marboxil, which could further be studied in laboratory and clinical trials for saving millions of lives around the world.</p>
Baloxavir, COVID-19, Ivermectin, Tadalafil
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250
https://www.ajmb.org/En/Article.aspx?id=30438
https://www.ajmb.org/PDF/En/FullText/30438.pdf
Ali Hassan Daghir Janabi41639